L9756

(−)-Tetramisole hydrochloride

powder, ≥99% (GC)

• Synonim(y): (S)-(−)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride, L(−)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride, Levamisole hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₁H₁₂N₂S · HCl
• Numer CAS: 16595-80-5
• Masa cząsteczkowa: 240.75
• NACRES: NA.77
• PubChem Substance ID: 24278526
• UNSPSC Code: 12352202
• EC Number: 240-654-6
• MDL number: MFCD00012675
• Beilstein/REAXYS Number: 4358988
• eCl@ss: 32150313

Właściwości

• Nazwa produktu: (−)-Tetramisole hydrochloride, ≥99% (GC)
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥99% (GC)
• form: powder
• input: mammalian sample(s)
• mp: 228-230 °C
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• antibiotic activity spectrum: parasites
• mode of action: enzyme | inhibits
• SMILES string: Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3
• InChI: 1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1
• InChI key: LAZPBGZRMVRFKY-HNCPQSOCSA-N

Opis

Application

Suitable for inhibition of various mammalian alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor).
Intestinal alkaline phosphatases are only slightly inhibited.
Not for veterinary use.

Biochem/physiol Actions

Shows both immunostimulant and immunosuppressant effects, depending on several controllable factors. Very effective in treatment of ascariasis (hookworm infestation). Useful in chemotherapy of colorectal cancers, possibly due to its stimulation of IL-1 production and direct activation of macrophages.

Other Notes

Levamisole hydrochloride is soluble in water at 50mg/mL yielding a clear, colorless solution. Solutions are stable at 2-8°C for ~1 month.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301
• Ostrzeżenia: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges