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M6045

2-Methyl-4-isothiazolin-3-one hydrochloride

≥99%

Synonim(y):

MIT hydrochloride, Methylisothiazolinone hydrochloride

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Rozmiar/SKUDostępnośćCena netto
1 g
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5 g
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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C4H5NOS · HCl
Numer CAS:
Masa cząsteczkowa:
151.61
UNSPSC Code:
51102829
NACRES:
NA.76
PubChem Substance ID:
EC Number:
247-499-3
Beilstein/REAXYS Number:
3993054
MDL number:

728,00 zł


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Quality Segment

biological source

synthetic

assay

≥99%

form

powder

concentration

≤ 100%

technique(s)

cell culture | mammalian: suitable

color

white to beige

mp

165—170 °C ((329 - 338 °F) at ca.990.4 hPa)

solubility

water: soluble 10.0 — 10.4 mg/mL, clear, colorless to faint yellow or tan

suitability

suitable for component for culture media

application(s)

microbiology

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

Cl[H].CN1SC=CC1=O

InChI

1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H

InChI key

SJXPQSRCFCPWQQ-UHFFFAOYSA-N

General description

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a derivative of the synthetic isothiazolinone.

Application

Methylisothiazolinone (MIT HCl) has been used:


  • as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
  • to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites

Biochem/physiol Actions

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT HCl is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.
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Ta pozycja
PHR1597500380
CMIT/MIT Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1597

CMIT/MIT

description

≥99%

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

ProClin™ preservative for use in IVD manufacturing, CMIT/MIT 1.5%, pkg of 400 mL

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

mode of action

protein synthesis | interferes

mode of action

-

mode of action

-

Quality Level

200

Quality Level

300

Quality Level

300

application(s)

microbiology

application(s)

pharmaceutical (small molecule)
pharmaceutical

application(s)

-

form

powder

form

liquid

form

liquid

suitability

suitable for component for culture media

suitability

-

suitability

-


Słowo ostrzegawcze

Danger

Klasa składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

PPE (środki ochrony indywidualnej)

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1A



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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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