M9020

Mecamylamine hydrochloride

≥98% (TLC), powder, nAChR antagonist

• Synonim(y): 2-(Methylamino)isocamphane hydrochloride, Inversine, N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₁H₂₁N · HCl
• Numer CAS: 826-39-1
• Masa cząsteczkowa: 203.75
• NACRES: NA.77
• PubChem Substance ID: 24277851
• UNSPSC Code: 12352116
• EC Number: 212-555-8
• MDL number: MFCD00151462
• Form: powder

Właściwości

• Nazwa produktu: Mecamylamine hydrochloride,
• form: powder
• Quality Segment: 200
• solubility: ethanol: 122 mg/mL, H₂O: 47 mg/mL, isopropanol: 476 mg/mL, glycerol: 95 mg/mL
• originator: AstraZeneca
• SMILES string: Cl.[H][C@@]12CC[C@@]([H])(C1)C(C)(NC)C2(C)C
• InChI: 1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11?;/m1./s1
• InChI key: PKVZBNCYEICAQP-CIISUUNXSA-N
• Gene Information: human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143) ;

Opis

Application

Mecamylamine hydrochloride has been used as an additive in extracellular saline during current-clamp recordings to reduce synaptic input. It has also been used as a non-selective nicotinic acetyl choline receptor blocker in aortic body neurons and in MLO-Y4 cells.

Biochem/physiol Actions

Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Disclaimer

Solutions are stable to autoclaving.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301
• Ostrzeżenia: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Faceshields, Gloves