This product is supplied as neat or pure liquid with a density of 1.02 g/mL and the molecular weight of 162.2 g/mole. The calculated molar concentration is 6.3 M. Ethanol is not present in the product, as received. This material is soluble in ethanol at 50 mg/mL, as listed in the 'Properties' section above. Based on the published density, this would be the equivalent of 49 uL per 1 mL of Ethanol.
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N0267
(±)-Nicotine
≥99% (TLC), nicotinic acetylcholine receptor agonist, liquid
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C10H14N2
Numer CAS:
Masa cząsteczkowa:
162.23
UNSPSC Code:
12352210
eCl@ss:
39151701
PubChem Substance ID:
NACRES:
NA.77
Beilstein/REAXYS Number:
82108
MDL number:
Assay:
≥99% (TLC)
Form:
liquid
Informacje o cenach i dostępności nie są obecnie dostępne.
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
(±)-Nicotine, ≥99% (TLC), liquid
Quality Segment
assay
≥99% (TLC)
form
liquid
optical activity
[α]25/D 0°(lit.)
color
yellow
solubility
ethanol: 50 mg/mL
density
1.02 g/mL at 25 °C (lit.)
SMILES string
CN1CCCC1c2cccnc2
InChI
1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
InChI key
SNICXCGAKADSCV-UHFFFAOYSA-N
Gene Information
human ... CHRNA2(1135), CHRNA3(1136), CHRNA4(1137)
rat ... Chrna3(25101), Chrna4(25590), Chrna7(25302)
Application
(±)-Nicotine has been used:
- as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
- as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
- as a test compound to study its effects on fibril formation
Biochem/physiol Actions
Prototype nicotinic acetylcholine receptor agonist.
(±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.
Packaging
The material is liquid, transparent, and viscous, packaged in amber vail, and the volume inserted into each bottle is very small, It may form a thin FILM on the sides. While it may be difficult to see the material inside by the eyes, the container is not empty.
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Słowo ostrzegawcze
Danger
Kody zagrożeń
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
Klasa składowania
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Temperatura zapłonu (°F)
213.8 °F - closed cup
Temperatura zapłonu (°C)
101 °C - closed cup
PPE (środki ochrony indywidualnej)
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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What concentration is the product given at? (Nicotine to Ethanol ratio)
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