O4636

Oxytetracycline dihydrate

Assay (anhydrous basis) 95.0%-102.0%

• Synonim(y): 5-Hydroxytetracycline dihydrate, Oxytetracycline, Oxytetracycline Anhydrous
• Wzór empiryczny (zapis Hilla): C₂₂H₂₄N₂O₉ · 2H₂O
• Numer CAS: 6153-64-6
• Masa cząsteczkowa: 496.46
• NACRES: NA.85
• PubChem Substance ID: 24898000
• UNSPSC Code: 51284038
• EC Number: 201-212-8
• MDL number: MFCD00151234

Właściwości

• Quality Segment: 200
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: protein synthesis | interferes
• SMILES string: O.[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
• InChI: 1S/C22H24N2O9.H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H2/t12-,13-,14+,17+,21-,22+;/m1./s1
• InChI key: IBZHEBHGZFICKS-IFLJXUKPSA-N

Opis

General description

Chemical structure: tetracycline

Application

Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. It is used in studies on the oxytetracycline-resistance gene (otrA) and is used for fluorescence measurements of hepatocytes.

Biochem/physiol Actions

Antibiotic produced by Streptomyces rimosus.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.

Oxytetracycline inhibits translation, which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome, inhibiting protein synthesis (elongation). The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.

Analysis Note

solubility very slightly solube in water, it dissolves in dilute acid and alkaline solutions

Other Notes

10g,50g

Keep container tightly closed in a dry and well-ventilated place.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS09
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H361d,H411
• Ostrzeżenia: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Hazard Classifications: Aquatic Chronic 2 - Repr. 2
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)