Wszystkie zdjęcia(1)

P0027

Sigma-Aldrich

Pyrvinium pamoate salt hydrate

≥98% (HPLC)

Synonim(y):
6-(Dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)-quinolinium, Vipyrvinium embonate, Altolat, NSC 223622, PP, Alnoxin, Pamovin, Vermitibier
Empirical Formula (Hill Notation):
C26H28N3 · 0.5 C23H14O6 · xH2O
Numer CAS:
Masa cząsteczkowa:
575.70 (anhydrous basis)
Identyfikator substancji w PubChem:

Poziom jakości

100

próba

≥98% (HPLC)

forma

powder

kolor

red

rozpuszczalność

DMSO: >10 mg/mL

inicjator

Pfizer

temp. przechowywania

room temp

SMILES string

O.CN(C)c1ccc2[n+](C)c(\C=C\c3cc(C)n(c3C)-c4ccccc4)ccc2c1.CN(C)c5ccc6[n+](C)c(\C=C\c7cc(C)n(c7C)-c8ccccc8)ccc6c5.Oc9c(cc%10ccccc%10c9Cc%11c(O)c(cc%12ccccc%11%12)C([O-])=O)C([O-])=O

InChI

1S/2C26H28N3.C23H16O6.H2O/c2*1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5;24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;/h2*6-18H,1-5H3;1-10,24-25H,11H2,(H,26,27)(H,28,29);1H2/q2*+1;;/p-2

InChI key

FGNOZQNUEDSSTR-UHFFFAOYSA-L

Powiązane kategorie

Zastosowanie

Pyrvinium pamoate salt hydrate has been used as an activator of casein kinase 1α (CK1α) in terminal blast phase of chronic myeloid leukemia (BP-CML) and human embryonic kidney (HEK293) cells. It has also been used as an inhibitor of β-catenin in Wilms tumor

Opakowanie

10, 50 mg in glass bottle

Działania biochem./fizjol.

Pyrvinium pamoate is a potent androgen receptor inhibitor. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors that reside in the cytoplasm and activated by testosterone and dihydrotestosterone. AR inhibitors have potential therapeutic benefit in prostate cancer; competitive inhibitors and chemical castration methods have been discovered, but both therapies have undesirable side effects and/or resistance potential. A screen for non-competitive inhibitors was performed, resulting in the discovery of pyrvinium as an AR inhibitor. In comparison to competitive inhibitors, this compound does not bind to the ligand-binding domain of AR or block DNA occupancy by AR, but it inhibits AR-dependent gene expression via a distinct signaling mechanism. It is more potent than classical competitive AR antagonists and exhibits synergy with other AR inhibitors.

Cechy i korzyści

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

piktogramy

Exclamation markHealth hazard

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

Klasyfikacja zagrożeń

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organy docelowe

Respiratory system

Kod klasy składowania

11 - Combustible Solids

WGK

WGK 3

Temperatura zapłonu °F

Not applicable

Temperatura zapłonu °C

Not applicable

Certyfikat analizy

Świadectwo pochodzenia

Zahra Anari et al.
Journal of food science, 84(8), 2199-2208 (2019-07-18)
Bioactive anthocyanins from aqueous extracts of muscadine grape pomace were concentrated using osmotic distillation (OD) and direct contact membrane distillation (DCMD) using polypropylene (PP) and poly(ethylene chlorotrifluoroethylene) (ECTFE) membranes. The driving force for OD is created by using a high
C Cabello-Alvarado et al.
Polymers, 11(7) (2019-07-25)
The study of polymeric nanocomposites is a possible alternative to conventional flame retardants. The aim of the present work is to investigate the effects of carbon-nanotubes (CNT) and TiO2 nanoparticles (NPs) on the thermo-mechanical, flammability, and electrical properties of polypropylene
Mehmet Mert et al.
Environmental science and pollution research international, 26(21), 21495-21510 (2019-05-28)
This study estimated unbalanced panel data analysis to investigate the relationship among CO2 emissions, GDP, renewable and non-renewable energy utilization, and foreign direct investment (FDI) inflow in 26 European countries. Moreover, we investigated the role of environmental regulations in validation
Lee-Ping Wang et al.
Journal of chemical theory and computation, 15(8), 4454-4467 (2019-07-19)
Born-Oppenheimer molecular dynamics (BOMD) is a promising simulation method for exploring the possible reaction pathways of a chemical system, but one significant challenge is the increased difficulty of converging the self-consistent field (SCF) calculation that often accompanies the breaking and
Shu-Chuan Liao et al.
Nanomaterials (Basel, Switzerland), 9(7) (2019-07-03)
: Cold plasma is an emerging technology offering many potential applications for regenerative medicine or tissue engineering. This study focused on the characterization of the carboxylic acid functional groups deposited on polymeric substrates using a plasma polymerization process with an

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