P2116

Pirfenidone

≥97% (HPLC), powder, antifibrotic agent

• Synonim(y): 5-Methyl-1-phenyl-2-(1H)-pyridone
• Wzór empiryczny (zapis Hilla): C₁₂H₁₁NO
• Numer CAS: 53179-13-8
• Masa cząsteczkowa: 185.22
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278625
• NACRES: NA.77
• MDL number: MFCD00866047
• Assay: ≥97% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Pirfenidone, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• solubility: H₂O: >10 mg/mL at 60 °C (warming for 30 minutes), DMSO: >20 mg/mL
• originator: Shionogi
• SMILES string: O=C(C=CC(C)=C1)N1C2=CC=CC=C2
• InChI: 1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
• InChI key: ISWRGOKTTBVCFA-UHFFFAOYSA-N

Opis

General description

Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) is a synthetic derivative of pyridine.

Application

Pirfenidone has been used:

• as a post-operative eye drop in rabbits to analyse its antifibrotic effect to improve glaucoma filtration surgery
• as an anti-scarring agent to examine whether it affects the foreign body reaction after glaucoma drainage device (GDD) implantation in a rabbit
• to test its antifibrotic potential in primary cultures of human orbital fibroblasts (hOFs)
• as tumor necrosis factor (TNFα) inhibitor to study its effect in hypoxia

Biochem/physiol Actions

Pirfenidone is used to treat idiopathic pulmonary fibrosis (IPF). It helps to decrease the weakening of lung function decline and ameliorate progression-free survival. Pirfenidone can repress the multiplication and contraction of collagen of human tenon′s fibroblasts.

Inhibits collagen production and fibroblast proliferation.

Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.

Features and Benefits

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves