P2928

Paxilline

≥98% (HPLC), Maxi-K potassium channel blocker, powder

• Wzór empiryczny (zapis Hilla): C₂₇H₃₃NO₄
• Numer CAS: 57186-25-1
• Masa cząsteczkowa: 435.56
• UNSPSC Code: 12352200
• PubChem Substance ID: 24898374
• NACRES: NA.77
• MDL number: MFCD00083464
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Paxilline, powder, ≥98% (HPLC)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• color: faintly yellow
• storage temp.: 2-8°C
• SMILES string: CC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C34C)C2=CC1=O
• InChI: 1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1
• InChI key: ACNHBCIZLNNLRS-UBGQALKQSA-N

Opis

General description

Paxilline is an indole diterpene metabolite produced by fungi. It has a functionalized pentacyclic core and is a template for the synthesis of a wide variety of derivatives.

Application

Paxilline has been used to block large conductance calcium activated potassium channels (BKCa) in murine smooth muscle cells and in myometrial cells of uterine samples. Paxilline acts as an agonist and activates liver X receptor in atlantic salmon.

Biochem/physiol Actions

Paxilline is a selective blocker of high-conductance Ca₂⁺-activated (Maxi-K) potassium channels. It also blocks big potassium (BK) channels.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Major toxin in Penicillium paxilli

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS05
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301 + H311 + H331,H315,H318,H335
• Ostrzeżenia: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Narządy docelowe: Respiratory system
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges