P4405

Podophyllotoxin

• Wzór empiryczny (zapis Hilla): C₂₂H₂₂O₈
• Numer CAS: 518-28-5
• Masa cząsteczkowa: 414.41
• UNSPSC Code: 12352200
• NACRES: NA.77
• PubChem Substance ID: 24277731
• EC Number: 208-250-4
• Beilstein/REAXYS Number: 99163
• MDL number: MFCD00075290
• Assay: ≥98%
• Form: powder

Właściwości

• assay: ≥98%
• Quality Segment: 200
• form: powder
• mp: 183-184 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: COc1cc(cc(OC)c1OC)[C@H]2C3C(COC3=O)[C@@H](O)c4cc5OCOc5cc24
• InChI: 1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
• InChI key: YJGVMLPVUAXIQN-XVVDYKMHSA-N

Opis

Application

Podophyllotoxin has been used as a reference compound for evaluating the cytotoxicity in VERO cells. It has also been used as a reference standard in high-performance liquid chromatography (HPLC).

Biochem/physiol Actions

Podophyllotoxin is a naturally occurring lignan obtained from resin podophyllin present in the genus Podophyllum. It exhibits antiviral and antimitotic properties. Podophyllotoxin may be used to treat anogenital warts in children and dermatological conditions caused by psoriasis vulgaris. It may also be used as a therapeutic agent to treat genital tumors, Wilms tumors, lung cancer, and lymphomas.

Inhibits microtubule assembly; antineoplastic.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301 + H311 + H331,H315,H319,H335
• Ostrzeżenia: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Narządy docelowe: Respiratory system
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges