P6273

2-Propylpentanoic acid

• Synonim(y): Valproic acid
• Wzór liniowy: (CH₃CH₂CH₂)₂CHCO₂H
• Numer CAS: 99-66-1
• Masa cząsteczkowa: 144.21
• NACRES: NA.25
• PubChem Substance ID: 24898751
• UNSPSC Code: 12352211
• EC Number: 202-777-3
• MDL number: MFCD00002672

Właściwości

• Quality Segment: 200
• refractive index: n20/D 1.425 (lit.)
• bp: 220 °C (lit.)
• solubility: H₂O: slightly soluble, alcohol: soluble
• density: 0.9 g/mL at 25 °C (lit.)
• lipid type: saturated FAs
• SMILES string: CCCC(C(O)=O)CCC
• InChI: 1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
• InChI key: NIJJYAXOARWZEE-UHFFFAOYSA-N
• Gene Information: human ... ALDH5A1(7915), CYP1A2(1544) ; mouse ... Hdac1(433759) ; rat ... Slc6a1(79212)

Opis

Application

2-Propylpentanoic acid has been used as a supplement in mouse embryonic fibroblast - conditioned medium (MEF-CM) to feed the cells.

Biochem/physiol Actions

2-Propylpentanoic acid is a short-chain fatty acid and potentially inhibits histone deacetylase action. It is known to promote tumor cell toxicity and increase susceptibility to radiation. 2-Propylpentanoic acid elevates the levels of γ-aminobutyric acid in the brain. Reduced central nervous system action is observed in overdosage of 2-propylpentanoic acid. It enhance the inhibitory action of γ-aminobutyric acid (GABA) by blocking voltage-dependent sodium channel.

Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS05,GHS07
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H302,H315,H318,H360FD
• Ostrzeżenia: P202 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Temperatura zapłonu (°F): 231.8 °F - closed cup
• Temperatura zapłonu (°C): 111 °C - closed cup
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter