P6628

Pilocarpine nitrate salt

≥98% (HPLC), muscarinic acetylcholine receptor agonist, powder

• Wzór empiryczny (zapis Hilla): C₁₁H₁₆N₂O₂ · HNO₃
• Numer CAS: 148-72-1
• Masa cząsteczkowa: 271.27
• NACRES: NA.77
• PubChem Substance ID: 57654548
• UNSPSC Code: 12352200
• EC Number: 205-723-7
• MDL number: MFCD00078497
• Beilstein/REAXYS Number: 4171406
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Pilocarpine nitrate salt, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]25/D +83°, c = 10 in H₂O(lit.)
• color: white
• solubility: H₂O: 100 mg/mL
• SMILES string: O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
• InChI: 1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
• InChI key: PRZXEPJJHQYOGF-GNAZCLTHSA-N
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Opis

Application

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

Biochem/physiol Actions

Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Nonselective muscarinic acetylcholine receptor agonist.

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS03,GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H272,H302,H330
• Ostrzeżenia: P210 - P220 - P260 - P264 - P301 + P312 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2
• Klasa składowania: 5.1B - Oxidizing hazardous materials
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges