P7265

Prostaglandin A₁

≥98% (HPLC), powder, NF-κB inhibitor

• Synonim(y): (13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA₁
• Wzór empiryczny (zapis Hilla): C₂₀H₃₂O₄
• Numer CAS: 14152-28-4
• Masa cząsteczkowa: 336.47
• NACRES: NA.77
• PubChem Substance ID: 24898834
• UNSPSC Code: 12352211
• MDL number: MFCD00077858
• Beilstein/REAXYS Number: 2003401
• Assay: ≥98%
• Form: powder

Właściwości

• Nazwa produktu: Prostaglandin A₁, synthetic
• biological source: synthetic
• Quality Segment: 200
• assay: ≥98%
• form: powder
• storage temp.: −20°C
• SMILES string: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1
• InChI: 1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
• InChI key: BGKHCLZFGPIKKU-LDDQNKHRSA-N

Opis

Biochem/physiol Actions

Prostaglandin A1 (PGA1) is a cyclopentenone prostaglandin containing chemically reactive α,β-unsaturated carbonyl. This cyclooxygenase 2 (COX-2) metabolic product aids in regulating the development and progression of Alzheimer′s disease (AD). In addition, PGA1 also regulates various biological processes via Michael addition. It exhibits antiviral activity against avian influenza A viruses (IAV) by inducing cytoprotective heat shock response in infected cells and by inhibiting nuclear factor-κB (NF-κB) activity.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H302,H360F
• Ostrzeżenia: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)