The lipase activity of this product is not less than 16 USP Units per mg (16 U/mg or IU/mg). This product is Pancreatin 8X USP, providing a minimum lipase activity eight times the USP requirement. A lot-specific unit value is not available. The product testing is on a pass/fail basis only.
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P7545
Pancreatin from porcine pancreas
8 × USP specifications
Synonim(y):
Pancreatin from hog pancreas
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
25 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 308,00 zł |
100 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 909,00 zł |
500 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2870,00 zł |
Informacje o tej pozycji
Specific activity:
8 × USP specifications
308,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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powder
Quality Segment
specific activity
8 × USP specifications
contains
lactose as extender
storage temp.
−20°C
Application
Pancreatin is a mixture of several digestive enzymes produced by the exocrine cells of the porcine pancreas. It is a broad-spectrum protease composed of amylase, trypsin, lipase, ribonuclease and protease. It is used for in vitro digestibility analysis. Product P7545 has been used to test the sensitivities of cellulolytic bacteria inhibitors.
The enzyme has been used along with amyloglucosidase for the in vitro digestion of starch in food samples. Pancreatin from Sigma has been used for in vitro pepsin-pancreatin digestion assays while estimating of lower gut digestibility using rumen feed residues. It has also been used along with pepsin to simulate in vitro gastric and ileal digestion of raw materials in pigs.
Biochem/physiol Actions
Due to the enzymatic components such as trypsin, amylase and lipase, pancreatin hydrolyzes proteins, starch and fats. Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40 °C, will digest not less than 25 times its weight of casein in 60 minutes at pH7.5 at 40 °C and will release not less than 2 microequivalents of acid per min per mg pancreatin from olive oil at pH9.0 at 37 °C.
Pancreatin contains enzymatic components including trypsin, amylase and lipase, ribonuclease, and protease, produced by the exocrine cells of the porcine pancreas. This combination of enzymes allows it to hydrolyze proteins, starch and fats. Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40°C, will digest not less than 25 times its weight of casein in 60 minutes at pH 7.5 at 40°C and will release not less than microequivalents of acid per min per mg pancreatin from olive oil at pH 9.0 at 37°C.
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Ta pozycja | |||
|---|---|---|---|
| description 8 × USP specifications | description 4 × USP specifications | description ≥3 × USP specifications | description powder, suitable for cell culture, 4 × USP specifications |
| specific activity 8 × USP specifications | specific activity 4 × USP specifications | specific activity ≥3 × USP specifications | specific activity 4 × USP specifications |
| form powder | form powder | form powder | form powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| contains lactose as extender | contains lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.) | contains - | contains lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.) |
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Słowo ostrzegawcze
Danger
Kody zagrożeń
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
Narządy docelowe
Respiratory system
Klasa składowania
11 - Combustible Solids
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Could you please provide the information about Lipase activity (U/mg)?
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Can you please tell us regarding trypsin range (concentration) in the pancreatin. We get it very low about 0.8U/mg when performed assays, is it normal or it is indicated as low activity.
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For P7545, we do not test the trypsin activity for this product.
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¿Este producto contiene colipasa?
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This product is not tested for the presence of colipase.
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Hello, I want to assess the effect of enzymes in pancreatin on fungus and fungal cell wall specially (with lipase), is there a recommended concentration to use for pancreatin solution? and what is the recommended dissolving solution in this case? Thanks
1 answer-
This product has not been tested in-house for the application of assessing the effect of enzymes in pancreatin on fungus and fungal cell walls, specifically with lipase. A recommended concentration has not been established. Conducting a literature search may provide guidance on this matter.
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Excuse me, is it possible to provide protease activity report for buyer? thank you very much and look forward to your reply.
1 answer-
This product meets 8X the minimum USP specifications. According to the USP monograph for Pancreatin, the 1X minimum specification is 25 USP units amylase, 2 USP units lipase, and 25 USP units protease per milligram. The calculated protease activity for the 8X preparation then, would be at least 200 units per milligram. This is a calculated value based on the USP monograph and are not reported separately on the Certificate of Analysis.
Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/p7545#product-documentationHelpful?
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Hi, what is the dissovled soultion? It can't dissolved in water or 1 mM HCl
1 answer-
This product is not tested for solubility. For assay purposes. it is dissolved at 40 mg/3mL PBS, pH 6.8. Trituration is required for 5 - 10 minutes. Historically, this product has also been dissolved in water at 20 mg/ml. with heating at 37 °C. This method yields a hazy solution.
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Is the product used for digestion cells in clinical laboratory? Can you please help me?
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This product is for research use only and is not suitable for in vitro diagnostic studies.
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What is the solubility of this enzyme in water?
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This product is soluble in water at up to 20 mg/ml in water. Heat may be required. This concentration will yield a hazy solution.
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What is the shelf life for this product?
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This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
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Bonjour, Que signifie exactement : '8 x SP specifications' ? Merci pour votre réponse
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The specific activity of this pancreatin is specified to be at least 8 x the minimum USP standard.
The USP defines a minimum specification of a 1 X Pancreatin as follows:
- 25 USP protease units per mg.
- 25 USP amylase units per mg.
- 2 USP lipase units per mg.Therefore, activity will be 8 times that.
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