P7903

Pipemidic acid

• Synonim(y): 8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid
• Wzór empiryczny (zapis Hilla): C₁₄H₁₇N₅O₃
• Numer CAS: 51940-44-4
• Masa cząsteczkowa: 303.32
• NACRES: NA.85
• PubChem Substance ID: 24898889
• UNSPSC Code: 51282938
• EC Number: 257-530-2
• MDL number: MFCD00057291

Właściwości

• form: powder
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: DNA synthesis | interferes, cell wall synthesis | interferes, enzyme | inhibits
• SMILES string: CCN1C=C(C(O)=O)C(=O)c2cnc(nc12)N3CCNCC3
• InChI: 1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)
• InChI key: JOHZPMXAZQZXHR-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544)

Opis

General description

Chemical structure: quinolone

Application

Pipemidic acid is used to study DNA damage and mutagenic activity. It has been used to induce articular lesions in the neonatal mouse and is used to study human lymphocyte blastogenesis and γ-interferon production .

Biochem/physiol Actions

Pipemidic acid modulates (inhibits) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Pipemidic acid has been shown to induce inhibition of lymphocyte DNA synthesis.

Analysis Note

Very slightly soluble in water. It dissolves in diluted solutions of acids and of alkali hydroxides.

Other Notes

10g,100g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H317,H334
• Ostrzeżenia: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Faceshields, Gloves