Q2763

Quinalizarin

≥95% (HPLC), powder, plasmodium falciparum casein kinase 2α (PfCK2α) inhibitor

• Synonim(y): 1,2,5,8-Tetrahydroxy-9,10-anthraquinone, 1,2,5,8-Tetrahydroxyanthraquinone, Alizarin Bordeaux BD, Alizarinbordeaux, Alizarine Bordeaux, Alizarine Bordeaux B, C.I. 58500, C.I. Mordant Violet 26, Khinalizarin, NSC 144046, NSC 4896, PHF 016
• Wzór empiryczny (zapis Hilla): C₁₄H₈O₆
• Numer CAS: 81-61-8
• Masa cząsteczkowa: 272.21
• UNSPSC Code: 12171500
• NACRES: NA.77
• PubChem Substance ID: 329823863
• EC Number: 201-366-6
• MDL number: MFCD00001205
• Colour Index Number: 58500
• Beilstein/REAXYS Number: 1889617
• Assay: ≥95% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Quinalizarin, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: red
• mp: ≥300 °C
• storage temp.: room temp
• SMILES string: Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O
• InChI: 1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H
• InChI key: VBHKTXLEJZIDJF-UHFFFAOYSA-N

Opis

Application

Quinalizarin has been used:

• as a casein kinase II (CKII) inhibitor to study its effect on CKII-mediated phosphorylation of importin α on subcellular scaling in sperm chromosomes and egg extract
• as a CKII inhibitor to study its ability to block parasite multiplication in a [3H]-hypoxanthine incorporation assay
• to study its effect on colorectal cancer (CRC) cell cycle arrest, cell apoptosis, and reactive oxygen species (ROS) generation in SW480 and HCT-116 cell lines

Biochem/physiol Actions

Studies show that quinalizarin can prevent the in vitro activity of recombinant Plasmodium falciparum casein kinase 2α (PfCK2α) catalytic subunit with an IC50 of 2μM.

Quinalizarin is a potent (IC50 = 110 nM), ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor.

Quinalizarin is a potent, ATP-competitive, and highly selective casein Kinase II (CK2) inhibitor.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07,GHS09
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302,H410
• Ostrzeżenia: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable