R101

Ranitidine hydrochloride

H2 histamine receptor antagonist;, solid

• Wzór empiryczny (zapis Hilla): C₁₃H₂₂N₄O₃S · HCl
• Numer CAS: 66357-59-3
• Masa cząsteczkowa: 350.86
• NACRES: NA.77
• PubChem Substance ID: 24277803
• UNSPSC Code: 12352200
• EC Number: 266-333-0
• MDL number: MFCD00069339
• Form: solid

Właściwości

• Nazwa produktu: Ranitidine hydrochloride, solid
• form: solid
• Quality Segment: 200
• color: tan
• solubility: H₂O: 1.8 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL
• originator: GlaxoSmithKline
• SMILES string: Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
• InChI: 1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
• InChI key: GGWBHVILAJZWKJ-CHHCPSLASA-N
• Gene Information: human ... HRH2(3274)

Opis

Application

Ranitidine hydrochloride has been used as a reference compound for the development and validation of parallel artificial membrane permeability assay (PAMPA).

Biochem/physiol Actions

H₂ histamine receptor antagonist; anti-ulcer agent.

Ranitidine is mainly used to treat gastrointestinal impairment instigated by non-steroidal anti-inflammatory drugs (NSAIDs).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H315,H317,H319,H334,H335
• Ostrzeżenia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Narządy docelowe: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)