R3375

Retinyl palmitate

Type IV, ~1,800,000 USP units/g, oil

• Synonim(y): Vitamin A palmitate, all−trans−Retinol palmitate
• Wzór empiryczny (zapis Hilla): C₃₆H₆₀O₂
• Numer CAS: 79-81-2
• Masa cząsteczkowa: 524.86
• UNSPSC Code: 12352205
• NACRES: NA.79
• PubChem Substance ID: 24899361
• EC Number: 201-228-5
• Beilstein/REAXYS Number: 1917366
• MDL number: MFCD00019414

Właściwości

• biological source: synthetic (organic)
• Quality Segment: 100
• type: Type IV
• assay: ≥90% (HPLC)
• form: oil
• specific activity: ~1,800,000 USP units/g
• color: yellow to orange
• mp: 26 °C
• storage temp.: 2-8°C
• SMILES string: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1
• InChI: 1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+
• InChI key: VYGQUTWHTHXGQB-FFHKNEKCSA-N

Opis

General description

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A, respectively. The retinoids comprise a cyclohexenyl ring with a 20-carbon with double bonds in cis and trans configuration. Retinyl palmitate is a major storage form of vitamin A. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.

Application

Retinyl palmitate has been used as:

• a retinoid derivative to modulate expression of connexin Cx26 and Cx30 in the cochlea
• a standard in high performance liquid chromatography(HPLC)
• as a retinoid substrate in the isomerase assay of eyecup protein homogenates

Biochem/physiol Actions

Review: Vitamin A metabolism.

Retinoids are ligands to nuclear receptors and have antioxidant functionality. Retinyl palmitate is widely used in pharmaceutical and cosmetic applications. In sunscreen, it protects from UVB-induced DNA damage and apoptosis. Retinyl palmitate is used to treat photoaging in skincare cosmetics. Retinyl palmitate is an effective chemopreventive agent to treat lung cancer. It also regulates various biological processes including cell differentiation and proliferation.

Packaging

Sealed ampule.

Physical form

Oil at room temperature

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H360D,H412
• Ostrzeżenia: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Aquatic Chronic 3 - Repr. 1B
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 2
• Temperatura zapłonu (°F): No data available
• Temperatura zapłonu (°C): No data available
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type ABEK (EN14387) respirator filter