RAB0978

Phosphotyrosine CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit

• NACRES: NA.32
• UNSPSC Code: 41116158
• Gene information: human ... CSF1R(1436)
• Species reactivity: human
• Storage temp.: −20°C
• Shipped in: wet ice

Właściwości

• species reactivity: human
• technique(s): ELISA: suitable
• assay range: inter-assay cv: <10%; intra-assay cv: <12%
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... CSF1R(1436)

Opis

General description

CSF1R (colony stimulating factor 1 receptor) or FMS, acts as a receptor for CSF1 and regulates monocyte and macrophage functioning. It is a member of the platelet-derived growth factor (PDGF) family of proteins and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.

The antibody pair provided in this kit recognizes Human Tyrosine-Phosphorylated-MCSFR.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

CSF1R (colony stimulating factor 1 receptor) and its ligand CSF1 are linked to poor prognosis in patients with solid tumors and in patients with female reproductive cancers. In breast cancers with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).

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Elementy zestawu są też dostępne oddzielnie

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Informacja o środkach bezpieczeństwa

• pictograms: GHS05
• signalword: Warning
• hcodes: H290
• pcodes: P234 - P390
• Hazard Classifications: Met. Corr. 1
• Klasa składowania: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable