S3147

5-Sulfosalicylic acid dihydrate

suitable for electrophoresis, ≥99%

• Synonim(y): 2-Hydroxy-5-sulfobenzoic acid
• Wzór liniowy: HO₃SC₆H₃-2-(OH)CO₂H·2H₂O
• Numer CAS: 5965-83-3
• Masa cząsteczkowa: 254.21
• UNSPSC Code: 41105319
• NACRES: NB.22
• PubChem Substance ID: 24899547
• EC Number: 202-555-6
• Beilstein/REAXYS Number: 650741
• MDL number: MFCD00149540

Właściwości

• Quality Segment: 200
• assay: ≥99%
• form: powder or crystals
• technique(s): electrophoresis: suitable
• impurities: ≤0.02% Insoluble matter, ≤0.05% Salicylic Acid
• mp: 105-110 °C (lit.)
• solubility: water: soluble 100 mg/mL, clear, colorless
• anion traces: chloride (Cl^-): ≤0.001%, sulfate (SO₄^2-): ≤0.035%
• cation traces: Fe: ≤0.001%, heavy metals (as Pb): ≤0.002%
• SMILES string: [H]O[H].[H]O[H].OC(=O)c1cc(ccc1O)S(O)(=O)=O
• InChI: 1S/C7H6O6S.2H2O/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10;;/h1-3,8H,(H,9,10)(H,11,12,13);2*1H2
• InChI key: BHDKTFQBRFWJKR-UHFFFAOYSA-N

Opis

General description

5-Sulfosalicylic acid is a strong acid capable of protonating water. It forms a new theophylline complex, which was investigated by X-ray photoelectron spectroscopy (XPS). It forms 1:1 proton-transfer compounds with the ortho-substituted monocyclic heteroaromatic Lewis bases. Their crystal structures have been studied.

Application

5-Sulfosalicylic acid dihydrate may be employed for the quantification of doxorubicin derived from PEGylated liposomal doxorubicin (Doxil) and its major metabolite in human plasma by HPLC. It may be used in the preparation of poly[[tris(di-2-pyridylamine)tris([μ]-5-sulfonatosalicylato)tricopper(II)] trihydrate].

5-Sulfosalicylic acid (3.5%) in 12% trichloroacetic acid is commonly used as a fixing solution for proteins in agarose and polyacrylamide gels.

Analysis Note

Tested for use in fixing solutions for PAGE, SDS-PAGE and IEF.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Klasa składowania: 8A - Combustible corrosive hazardous materials
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves