S5637

Sulfamethazine sodium salt

≥98%

• Synonim(y): 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide
• Wzór liniowy: C₁₂H₁₃N₄O₂SNa
• Numer CAS: 1981-58-4
• Masa cząsteczkowa: 300.31
• NACRES: NA.85
• PubChem Substance ID: 24899666
• UNSPSC Code: 51284910
• EC Number: 217-840-0
• MDL number: MFCD00068333

Właściwości

• Quality Segment: 200
• assay: ≥98%
• form: powder
• storage condition: (Keep container tightly closed in a dry and well-ventilated place.)
• color: white to off-white
• solubility: H₂O: soluble 50 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: [Na].Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
• InChI: 1S/C12H14N4O2S.Na.H/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;;/h3-7H,13H2,1-2H3,(H,14,15,16);;
• InChI key: WIVZAHIZHZEEOX-UHFFFAOYSA-N

Opis

General description

Chemical structure: sulfonamide

Application

Sulfamethazine is an antibiotic used to clinically treat bronchitis, prostatitis and urinary tract infections. It is used in disposition and depletion kinetic studies. It is used to develop detection techniques for quantification in fluids such as cows′ milk, honey and swine urine.

Biochem/physiol Actions

Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

Packaging

25G,100G

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable