Merck
Wszystkie zdjęcia(3)

S7067

Sigma-Aldrich

SB 202190

≥98% (HPLC)

Synonim(y):
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
Empirical Formula (Hill Notation):
C20H14FN3O
Numer CAS:
Masa cząsteczkowa:
331.34
Numer MDL:
Identyfikator substancji w PubChem:
NACRES:
NA.77

Poziom jakości

100

próba

≥98% (HPLC)

forma

powder

kolor

faintly yellow, to beige

rozpuszczalność

DMSO: 10 mg/mL, clear

inicjator

GlaxoSmithKline

temp. przechowywania

2-8°C

SMILES string

Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4

InChI

1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)

InChI key

QHKYPYXTTXKZST-UHFFFAOYSA-N

Gene Information

human ... MAPK14(1432)

Zastosowanie

SB 202190 was used to inhibit p38 activation in MCF7 cells5, mouse macrophages6 and HepG2 cells.7

Opakowanie

5, 25 mg in glass bottle

Działania biochem./fizjol.

SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase. SB 202190 binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms.

Cechy i korzyści

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informacje prawne

Sold for research purposes under agreement from Glaxo­Smith­Kline

Kod klasy składowania

13 - Non Combustible Solids

WGK

WGK 3

Temperatura zapłonu °F

Not applicable

Temperatura zapłonu °C

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Gloves

Certyfikat analizy

Wprowadź numer partii, aby wyszukać certyfikat analizy (COA).

Świadectwo pochodzenia

Wprowadź numer partii, aby wyszukać świadectwo pochodzenia (COO).

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