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S7651

Sphingomyelinase from Bacillus cereus

lyophilized powder, ≥100 units/mg protein

Synonim(y):

Sphingomyelin choline phosphohydrolase, Sphingomyelin phosphodiesterase

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Rozmiar/SKUDostępnośćCena netto
10 units
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
397,00 zł
50 units
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
1380,00 zł

Informacje o tej pozycji

Numer CAS:
9031-54-3
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-869-9
MDL number:
MFCD00132362
Numer WE:
3.1.4.12 (BRENDA, IUBMB)
Specific activity:
≥100 units/mg protein

397,00 zł

Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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form

lyophilized powder

Quality Segment

specific activity

≥100 units/mg protein

mol wt

36873 Da

composition

Protein, ~10% Lowry

storage temp.

2-8°C

Gene Information

Bacillus cereus ATCC 14579 ... BC0671(1203022)

General description

Sphingomyelinase modulates adenosine triphosphate (ATP)-independent endocytosis of fibroblast and large vesicles of macrophages. Sphingomyelinase causes hemolysis of human erythrocytes. It is also a potent virulence factor leading to invasive diseases.
Sphingomyelinase from Bacillus cereus (Bc-Smase) is a Mg2+-containing metalloenzyme. Bacillus cereus sphingomyelinase induces hemolysis of sheep erythrocytes.

Application

Sphingomyelinase from Bacillus cereus has been used:
  • in the measurement of membrane capacitance in brain slices
  • for testing and confirming its silkworm-killing activity
  • in enzyme activity assay and for elucidating its effect on hydrolysis of sphingomyelin in complex lipid mixtures

Sphingomyelinase has been used in a study to investigate skeletal manifestations in pediatric and adult patients with Niemann Pick disease.

Biochem/physiol Actions

Initiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.

Physical form

Lyophilized powder containing potassium phosphate buffer salts and stabilizer.

Other Notes

One unit will hydrolyze 1.0 μmole of TNPAL-sphingomyelin per min at pH 7.4 at 37 °C.
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S9396S8633P5542
Sphingomyelinase from Bacillus cereus lyophilized powder, ≥100 units/mg protein

Sigma-Aldrich

S7651

Sphingomyelinase from Bacillus cereus

Sphingomyelinase from Bacillus cereus buffered aqueous glycerol solution, ≥100 units/mg protein (Lowry)

Sigma-Aldrich

S9396

Sphingomyelinase from Bacillus cereus

Sphingomyelinase from Staphylococcus aureus buffered aqueous glycerol solution, 100-300 units/mg protein (Lowry)

Sigma-Aldrich

S8633

Sphingomyelinase from Staphylococcus aureus

Phospholipase C, Phosphatidylinositol-specific from Bacillus cereus lyophilized powder, ≥1,000 units/mg protein (Lowry)

Sigma-Aldrich

P5542

Phospholipase C, Phosphatidylinositol-specific from Bacillus cereus

description

lyophilized powder, ≥100 units/mg protein

description

buffered aqueous glycerol solution, ≥100 units/mg protein (Lowry)

description

buffered aqueous glycerol solution, 100-300 units/mg protein (Lowry)

description

lyophilized powder, ≥1,000 units/mg protein (Lowry)

specific activity

≥100 units/mg protein

specific activity

≥100 units/mg protein (Lowry)

specific activity

100-300 units/mg protein (Lowry)

specific activity

≥1,000 units/mg protein (Lowry)

Gene Information

Bacillus cereus ATCC 14579 ... BC0671(1203022)

Gene Information

Bacillus cereus ATCC 10987 ... spH(2751530)

Gene Information

-

Gene Information

Bacillus cereus E33L ... BCZK3513(3026815)

form

lyophilized powder

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

lyophilized powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

mol wt

36873 Da

mol wt

34.2 kDa

mol wt

-

mol wt

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

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Klasa składowania

11 - Combustible Solids

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

PPE (środki ochrony indywidualnej)

Eyeshields, Gloves, type N95 (US)

Piktogramy

Health hazard
GHS08

Słowo ostrzegawcze

Danger

Kody zagrożeń

H334

Ostrzeżenia

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Co się dzieje?

WGK 1

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Questions

  1. Hi for product number S7651, Sphingomyelinase from Bacillus cereus, once prepared how long can the Sphingomyelinase solution be kept and should it be kept at 2-8C or -20C?

    1 answer

    1. This product is stable for several days when stored refrigerated. Prepared solutions in aqueous buffers containing 50 % Glycerol are stable for extended periods when refrigerated.

      To review these product options please see the link below:
      https://www.sigmaaldrich.com/search/9031-54-3?focus=products&page=1&perpage=30&sort=relevance&term=9031-54-3&type=product

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