S8753

Strychnine hydrochloride

glycine receptor antagonist

• Wzór empiryczny (zapis Hilla): C₂₁H₂₂N₂O₂ · HCl
• Numer CAS: 1421-86-9
• Masa cząsteczkowa: 370.87
• NACRES: NA.32
• PubChem Substance ID: 24899812
• UNSPSC Code: 12352210
• EC Number: 215-826-9
• MDL number: MFCD00058174

Właściwości

• Nazwa produktu: Strychnine hydrochloride,
• Quality Segment: 100
• SMILES string: Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]
• InChI: 1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1
• InChI key: VLXYTKMPCOQKEM-ZEYGOCRCSA-N

Opis

Application

Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.

Biochem/physiol Actions

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS09
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H300 + H330,H410
• Ostrzeżenia: P260 - P264 - P271 - P273 - P284 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges