SML0036

Procarbazine hydrochloride

≥98% (HPLC)

• Synonim(y): N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₂H₁₉N₃O·HCl
• Numer CAS: 366-70-1
• Masa cząsteczkowa: 257.76
• NACRES: NA.77
• PubChem Substance ID: 329825106
• UNSPSC Code: 12352200
• EC Number: 206-678-6
• MDL number: MFCD00072082
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥18 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.CNNCc1ccc(cc1)C(=O)NC(C)C
• InChI: 1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
• InChI key: DERJYEZSLHIUKF-UHFFFAOYSA-N

Opis

Application

Procarbazine, an antineoplastic alkylating agent, may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an anticancer agent. It may be used to study new combination of anticancer drugs.

Procarbazine hydrochloride has been used to study its physicochemical property.

Biochem/physiol Actions

Procarbazine hydrochloride is a Antineoplastic alkylating agent

Procarbazine is an antineoplastic alkylating agent widely used in cancer chemotherapy in combination with other compounds. It has multiple mechanisms of action. Procarbazine inhibits protein, RNA and DNA synthesis in addition to being an alkylating agent.

Procarbazine is metabolized to azoprocarbazine either by cytochrome P450 enzyme and monoamine oxidase in an NADPH (nicotinamide adenine diphosphate) dependent or independent manner. It is considered neurotoxic. Procarbazine is used in combination with therapy for treating Hodgkin′s disease.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H302,H341,H350,H360
• Ostrzeżenia: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Repr. 1A
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable