SML0233

Ro 61-8048

≥98% (HPLC)

• Synonim(y): 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide, Ro-61-8048
• Wzór empiryczny (zapis Hilla): C₁₇H₁₅N₃O₆S₂
• Numer CAS: 199666-03-0
• Masa cząsteczkowa: 421.45
• NACRES: NA.77
• PubChem Substance ID: 329825246
• UNSPSC Code: 12352200
• MDL number: MFCD11040807
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: faintly yellow to yellow
• solubility: DMSO: ≥15 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1OC)S(=O)(=O)Nc2nc(cs2)-c3cccc(c3)[N+]([O-])=O
• InChI: 1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)
• InChI key: NDPBMCKQJOZAQX-UHFFFAOYSA-N

Opis

Application

Ro 61-8048 has been used as a kynurenine 3-monooxygenase (KMO) inhibitor to study its effects on nicotinamide adenine dinucleotide (NAD⁺) concentration in hepatocytes of mice.

Biochem/physiol Actions

Ro 61-8048 is a potent kynurenine 3-monooxygenase (KMO) inhibitor

Ro 61-8048 is an inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain.

Inhibition of kynurenine 3-hydroxylase by Ro 61-8048 reduces the episodes of dystonia and dyskinesias induced by decreased levels of kynurenic acid.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3