SML0256

2OHOA

≥98% (HPLC)

• Synonim(y): (9Z)-2-Hydroxy-9-octadecenoic acid; cis-2-Hydroxy-9-octadecenoic acid, 2-Hydroxy Oleic Acid, Minerval
• Wzór empiryczny (zapis Hilla): C₁₈H₃₄O₃
• Numer CAS: 56472-29-8
• Masa cząsteczkowa: 298.46
• NACRES: NA.77
• PubChem Substance ID: 329825264
• UNSPSC Code: 12352200
• MDL number: MFCD07778553
• Assay: ≥98% (HPLC)
• Storage condition: protect from light

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• storage condition: protect from light
• color: white to tan
• solubility: DMSO: >20 mg/mL
• storage temp.: room temp
• SMILES string: CCCCCCCC\C=C/CCCCCCC(O)C(O)=O
• InChI: 1S/C18H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h9-10,17,19H,2-8,11-16H2,1H3,(H,20,21)/b10-9-
• InChI key: JBSOOFITVPOOSY-KTKRTIGZSA-N

Opis

Application

2OHOA has been used as:

• a modulator of the sphingolipid and glycerophospholipid pathway to study its effects on myelination in mice Charcot–Marie–Tooth type 1A (CMT1A) myelinopathy and myelinating dorsal root ganglia cultures
• in biophysical studies to study its effects on artificial membranes
• to study its interactions with major membrane lipid films

Biochem/physiol Actions

2OHOA induces cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2OHOA increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.

2OHOA is an antitumor agent; sphingomyelin synthase activator.

2-Hydroxy oleic acid (2OHOA) is a derivative of oleic acid. It plays a role in membrane organization, alterations in membrane fluidity, an increase of the tendency to form non-lamellar structures, and remodeling of microdomains by interacting with the lipids in membranes of pathological cells.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS05
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H318
• Ostrzeżenia: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable