SML0293

Telbivudine

≥98% (HPLC)

• Synonim(y): β-L-Thymidine, 1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-Pyrimidinedione, 2′-Deoxy-L-thymidine, Epavudine, L-Thymidine, NV 02B, Sebivo
• Wzór empiryczny (zapis Hilla): C₁₀H₁₄N₂O₅
• Numer CAS: 3424-98-4
• Masa cząsteczkowa: 242.23
• NACRES: NA.77
• PubChem Substance ID: 329825300
• UNSPSC Code: 12352200
• MDL number: MFCD02683612
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -15 to -22°, c = 1 in H₂O
• color: white to beige
• solubility: H₂O: 10 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: CC1=CN([C@@H]2C[C@@H](O)[C@H](CO)O2)C(=O)NC1=O
• InChI: 1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1
• InChI key: IQFYYKKMVGJFEH-CSMHCCOUSA-N

Opis

Application

Telbivudine has been used to explore the mechanisms of telbivudine (LdT) induced creatine kinase (CK) elevation.

Biochem/physiol Actions

Telbivudine is a nucleoside analog that is widely used to treat hepatitis B virus (HBV) infection.

Telbivudineis a Hepatitis B antiviral agent.

Telbivudine is a synthetic molecule containing β-L-configuration. Telbivudine improves the estimated glomerular filtration rate (eGFR) in response to chronic hepatitis B (CHB). It prevents perinatal transmission and enhances the hepatitis B e antigen (HBeAg) seroconversion. It is also known to cause side effects such as creatine kinase (CK) elevation and fatal rhabdomyolysis.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable