SML0307

Pleconaril

≥98% (HPLC), VP1 capsid protein binder, powder

• Synonim(y): 3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole, VP 63843, Win 63843
• Wzór empiryczny (zapis Hilla): C₁₈H₁₈F₃N₃O₃
• Numer CAS: 153168-05-9
• Masa cząsteczkowa: 381.35
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825312
• NACRES: NA.77
• MDL number: MFCD00923611
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Pleconaril, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥10 mg/mL (warmed)
• storage temp.: room temp
• SMILES string: Cc1cc(CCCOc2c(C)cc(cc2C)-c3noc(n3)C(F)(F)F)on1
• InChI: 1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3
• InChI key: KQOXLKOJHVFTRN-UHFFFAOYSA-N

Opis

General description

Pleconaril is a drug, that has antiviral activity.

Application

Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.

Biochem/physiol Actions

Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent that binds to hydrophobic pocket in VP1 major capsid protein. Also, pleconaril delays the onset of diabetes in experimental animals infected with Ljungan virus (LV).

Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent.

Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301,H413
• Ostrzeżenia: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable