SML0327

AM630

≥90% (HPLC), CP 55,940 antagonist, powder

• Synonim(y): 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone, AM 630, Iodopravadoline
• Wzór empiryczny (zapis Hilla): C₂₃H₂₅IN₂O₃
• Numer CAS: 164178-33-0
• Masa cząsteczkowa: 504.36
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825332
• NACRES: NA.77
• MDL number: MFCD01861183
• Assay: ≥90% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Nazwa produktu: AM630, ≥90% (HPLC)
• Quality Segment: 100
• description: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet
• assay: ≥90% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1)C(=O)c2c(C)n(CCN3CCOCC3)c4cc(I)ccc24
• InChI: 1S/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3
• InChI key: JHOTYHDSLIUKCJ-UHFFFAOYSA-N

Opis

Application

AM630 has been used:

• as a cannabinoid 2(CB2) inhibitor to study the analgesic effect exerted by polysaccharopeptide from Trametes versicolor (TPSP).
• as a CB2 antagonist along with β-caryophyllene (BCP) to study its effects on re-epithilialization of fibroblast cells.
• as a CB2 antagonist to study its interaction with 17-β-estradiol in primary human osteoblasts.

Biochem/physiol Actions

AM630 is a selective CB2 cannabinoid antagonist/inverse agonist (Ki = 31.2 nM) with > 150-fold selectivity over CB1 receptors.

AM630 is a selective CB2 cannabinoid antagonist/inverse agonist.

AM630 is an aminoalkylindole and acts as a competitive antagonist of CP 55,940 and WIN 55,212-2. It also behaves as a competitive antagonist of anandamide and (R)-(+)-arachidonyl-1′-hydroxy-2′-propylamide (AM356).

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS09
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H410
• Ostrzeżenia: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable