SML0346

Alosetron hydrochloride

≥98% (HPLC)

• Synonim(y): 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₇H₁₈N₄O·HCl
• Numer CAS: 122852-69-1
• Masa cząsteczkowa: 330.81
• NACRES: NA.77
• PubChem Substance ID: 329825350
• UNSPSC Code: 12352200
• MDL number: MFCD09028027
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: ≥5 mg/mL at warmed
• storage temp.: 2-8°C
• SMILES string: CN1C2=C(C=CC=C2)C3=C1CCN(CC4=C(C)N=CN4)C3=O.Cl
• InChI: 1S/C17H18N4O.ClH/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;/h3-6,10H,7-9H2,1-2H3,(H,18,19);1H
• InChI key: FNYQZOVOVDSGJH-UHFFFAOYSA-N
• Gene Information: human ... HTR3A(3359)

Opis

Biochem/physiol Actions

Alosetron is a potent and highly selective antagonist of serotonin 5-HT3 receptors, nonselective cation channels found predominantly in the enteric nervous system of the gastrointestinal tract. These receptors are involved in the regulation of visceral pain, colonic transit and GI secretions that can contribute to the pathophysiology of irritable bowel syndrome (IBS). Alosetron is used clinically for treatment of women with severe diarrhea-predominant IBS.

Alosetron is a potent and highly selective antagonist.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301,H319,H412
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Ostrzeżenia: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313