SML0371

MLR-1023

≥98% (HPLC), Lyn kinase activator, powder

• Synonim(y): 5-(3-Methylphenoxy)- 2(1H)-pyrimidinone, CP 26154, NSC 314335, Tolimidone
• Wzór empiryczny (zapis Hilla): C₁₁H₁₀N₂O₂
• Numer CAS: 41964-07-2
• Masa cząsteczkowa: 202.21
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825372
• NACRES: NA.77
• MDL number: MFCD00866900
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: MLR-1023, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL (clear solution)
• storage temp.: room temp
• SMILES string: Cc1cccc(OC2=CNC(=O)N=C2)c1
• InChI: 1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14)
• InChI key: HJQILFPVRNHTIG-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

MLR-1023 is a potent, orally active, allosteric activator of the non-receptor Src-related Lyn kinase that produces lasting glucose lowering, reduces HbA1c levels, and preserves pancreatic β-cells in db/db mice. MLR-1023 increased insulin receptor sensitivity. MLR-1023 (Tolimidone) is antiulcer agent.

MLR-1023 is a potent, orally active, allosteric activator of the non-receptor Src-related Lyn kinase; insulin receptor-potentiating agent; antiulcer agent.

MLR-1023 has a therapeutic potential to treat type 2 diabetes.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H319
• Ostrzeżenia: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable