SML1010

L-742001 hydrochloride

≥98% (HPLC)

• Synonim(y): (Z)-4-[1-Benzyl-4-[(4-chlorophenyl)methyl]piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid hydrochloride, 4-[4-[(4-Chlorophenyl)methyl]-1-(phenylmethyl)-4-piperidinyl]-2-hydroxy-4-oxo-2-butenoic acid hydrochloride, L-742,001 hydrochloride, L742001 hydrochloride
• Wzór empiryczny (zapis Hilla): C₂₃H₂₄ClNO₄ · HCl
• Numer CAS: 174605-64-2
• Masa cząsteczkowa: 450.35
• NACRES: NA.77
• PubChem Substance ID: 329825629
• UNSPSC Code: 51111800
• MDL number: MFCD22587878
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O/C(C(O)=O)=C\C(C(CC1)(CC2=CC=C(Cl)C=C2)CCN1CC3=CC=CC=C3)=O.Cl
• InChI: 1S/C23H24ClNO4.ClH/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18;/h1-9,14,26H,10-13,15-16H2,(H,28,29);1H/b20-14-;
• InChI key: LMLNSXCRZNNZBT-VSOKSMTPSA-N

Opis

Biochem/physiol Actions

L-742,001 is an inhibitor of the influenza virus RNA polymerase PA subunit.

L-742,001 is an inhibitor of the influenza virus RNA polymerase PA subunit, implicated in several roles, including endonuclease and protease activities as well as viral RNA/complementary RNA promoter binding. L-742,001 inhibits the influenza endonuclease-dependent polymerase activity with an IC₅₀ of 430 nM.

L-742001 is useful in the treatment of influenza viral infection.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07,GHS09
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302,H410
• Ostrzeżenia: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable