SML1083

Ethacrynic acid

≥97% (HPLC), glutathione S-transferase inhibitor, powder

• Synonim(y): 2-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid, ECA, Etacrynic acid, [2,3-Dichloro-4-(2-ethylacryloyl)phenoxy]acetic acid, (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid
• Wzór empiryczny (zapis Hilla): C₁₃H₁₂Cl₂O₄
• Numer CAS: 58-54-8
• Masa cząsteczkowa: 303.14
• NACRES: NA.77
• PubChem Substance ID: 329825461
• UNSPSC Code: 12352106
• EC Number: 200-384-1
• MDL number: MFCD00056693
• Assay: ≥97% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Ethacrynic acid, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O
• InChI: 1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
• InChI key: AVOLMBLBETYQHX-UHFFFAOYSA-N
• Gene Information: human ... SLC12A1(6557)

Opis

Biochem/physiol Actions

Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.

Ethacrynic acid increases the cytotoxicity of chlorambucil in rat and human tumor cell lines.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable