SML1356

Sephin1

≥95% (HPLC)

• Synonim(y): (E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide, Sephin 1
• Wzór empiryczny (zapis Hilla): C₈H₉ClN₄
• Numer CAS: 951441-04-6
• Masa cząsteczkowa: 196.64
• NACRES: NA.77
• PubChem Substance ID: 329825811
• UNSPSC Code: 12352200
• MDL number: MFCD00790608
• Assay: ≥95% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NC(N/N=C/C1=CC=CC=C1Cl)=N
• InChI: 1S/C8H9ClN4/c9-7-4-2-1-3-6(7)5-12-13-8(10)11/h1-5H,(H4,10,11,13)/b12-5+
• InChI key: PDWJALXSRRSUHR-LFYBBSHMSA-N

Opis

Biochem/physiol Actions

Sephin1 is a selective inhibitor of a holophosphatase. It is a guanabez derivative that binds to and inhibits a regulatory subunit of the stress-induced protein phosphatase 1 (PPP1R15A), but not the constitutive PPP1R15B, and lacks α2-adrenergic activity. Phosphorylation of eIF2α, α subunit of eukaryotic translation initiation factor 2, reduces protein synthesis and prevents the accumulation of misfolded protein in the endoplasmic reticulum (ER). PPP1R15A recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate eIF2α, so inhibiting PPP1R15A activity prolongs the phosphorylation of eIF2α and aids in its prevention of the accumulation of misfolded protein. In vitro Sephin1 protected cells from lethal protein misfolding and cytotoxic ER stress. In vivo sephin1 prevented two unrelated protein misfolding diseases in mice (Charchot-Marie-Tooth 1B and ALS).

Sephin1 is a selective inhibitor of protein phosphatase 1 (PPP1R15A).

In vivo studies using mice models show that sephin1 suppresses neurodegeneration, by preventing eIF2α (eukaryotic initiation factor 2) dephosphorylation.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301
• Ostrzeżenia: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable