SML1656

CBR-5884

≥98% (HPLC)

• Synonim(y): 5-[(2-Furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylic acid ethyl ester
• Wzór empiryczny (zapis Hilla): C₁₄H₁₂N₂O₄S₂
• Numer CAS: 681159-27-3
• Masa cząsteczkowa: 336.39
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825995
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: paste

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: paste
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC1=C(C(OCC)=O)SC(NC(C2=CC=CO2)=O)=C1SC#N
• InChI: 1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H,3H2,1-2H3,(H,16,17)
• InChI key: QBVIRPJBDIZKBC-UHFFFAOYSA-N

Opis

Application

CBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and also used in trypan blue exclusion assay to determine the number of viable MYCN cells.

Biochem/physiol Actions

CBR-5884 is a cell penetrant, potent and selective noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) that inhibits proliferation of melanoma and breast cancer lines. CBR-5884 inhibits de novo serine synthesis in in cancer cells.

CBR-5884 is a cell penetrant, potent and selective noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH).

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H315,H319,H335
• Ostrzeżenia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Narządy docelowe: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable