SML1933

TP-472N

≥98% (HPLC)

• Synonim(y): 1-[8-[2-(Cyclopropylmethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-6-yl]-ethanone
• Wzór empiryczny (zapis Hilla): C₁₉H₁₈N₂O₂
• Numer CAS: 2080306-24-5
• Masa cząsteczkowa: 306.36
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD30720894
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C)C1=CC(C2=CC=CC=C2OCC3CC3)=C4N=CC=CN41
• InChI key: IDQWBZAMTQTECP-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Negative control probe for TP-472, a bromodomain BRD9/7 probe

TP-472N is a negative control probe for TP-472. TP-472 is a selective probe for bromodomain-containing proteins BRD9 and BRD7. The BRD9/7 probe was developed out of a collaborative effort by Takeda and the SGC, and is of a different chemotype from BRD9/7 probes previously available. TP-472 has a KD value of 33nM for BRD9 and 340nM for BRD7 by ITC, is >30 fold selective for BRD9 over all other bromodomain family members except BRD7, and is suitable for in vivo applications. The negative control TP-472N is inactive against other bromodomains (>20μM against BRD9). For full characterization details of TP-472 and TP-472N, please visit the TP-472 probe summary on the Structural Genomics Consortium (SGC) website.

TP-472, the active BRD9/7 probe, is available from Sigma. To learn more about and purchase TP-472, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

TP-472N is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable