SML1935

Nimorazole

≥98% (HPLC)

• Synonim(y): 4-(2-(5-Nitro-1H-imidazol-1-yl)ethyl)morpholine, K 1900, K-1900, K1900, NSC 107524, NSC-107524, NSC107524
• Wzór empiryczny (zapis Hilla): C₉H₁₄N₄O₃
• Numer CAS: 6506-37-2
• Masa cząsteczkowa: 226.23
• UNSPSC Code: 12352200
• EC Number: 229-394-4
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 30 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [N+](=O)([O-])c1[n](cnc1)CCN2CCOCC2
• InChI: 1S/C9H14N4O3/c14-13(15)9-7-10-8-12(9)2-1-11-3-5-16-6-4-11/h7-8H,1-6H2
• InChI key: MDJFHRLTPRPZLY-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

A nitroimidazole-based hypoxic cell-radiation sensitizer and anti-infective against Trichomonas vaginalis.

Nimorazole is a nitroimidazole-based hypoxic cell-radiation sensitizer with less toxicity than etanidazole or misonidazole. Under low oxygen (hypoxic) condition, reductive activation of its 5-nitroimidazole moiety leads to enhanced adduct formation with reduced glutathione, which form the basis of cancer/tumour-selective radiation sensitization. Nimorazole is also a known anti-infective agent against trichomoniasis, an infectious disease caused by the protozoan parasite Trichomonas vaginalis.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H340,H361d
• Ostrzeżenia: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 1B - Repr. 2
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable