SML2259

Lapatinib

≥98% (HPLC), EGFR/ErbB1 and HER2/ErbB2 inhibitor, powder

• Synonim(y): Lapatinib, GD 2016, GSK 572016, GW-572016, GW572016, N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine, N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine
• Wzór empiryczny (zapis Hilla): C₂₉H₂₆ClFN₄O₄S
• Numer CAS: 231277-92-2
• Masa cząsteczkowa: 581.06
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD09264194
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Lapatinib, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CS(=O)(CCNCC1=CC=C(C2=CC=C3N=CN=C(C3=C2)NC4=CC=C(C(Cl)=C4)OCC5=CC=CC(F)=C5)O1)=O
• InChI: 1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)
• InChI key: BCFGMOOMADDAQU-UHFFFAOYSA-N
• Gene Information: human ... EGFR(1956), ERBB2(2064)

Opis

Biochem/physiol Actions

Lapatinib acts as a dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR/ErbB1) and human epidermal growth factor receptor 2 (HER2/ErbB2). It competes for its binding site on the tyrosine kinase domain with adenosine triphosphate (ATP). Lapatinib mediates has been studied in vitro in the inhibition of cell growth as well as and apoptosis induction in several human cancer cells such as breast, lung, vulva, gastric, and head and neck cancer.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H361d,H362,H373,H413
• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Narządy docelowe: Liver
• Ostrzeżenia: P202 - P260 - P263 - P264 - P273 - P308 + P313
• Hazard Classifications: Aquatic Chronic 4 - Lact. - Repr. 2 - STOT RE 2