SML2345

Rhynchophylline

From Uncaria rhynchophylla, ≥95% (HPLC), NMDA receptor antagonist, powder

• Synonim(y): (αE,1′R,6′R,7′S,8′aS)-6′-Ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo- Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid methyl ester, (7β,16E,20α)-16,17-Didehydro-17-methoxy-2-oxo-corynoxan-16-carboxylic acid methyl ester, Mitrinermin, NSC 21731, Rhynchophyllin, Rhyncophylline, Mitrinermine
• Wzór empiryczny (zapis Hilla): C₂₂H₂₈N₂O₄
• Numer CAS: 76-66-4
• Masa cząsteczkowa: 384.47
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00221748
• Assay: ≥95% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Rhynchophylline, ≥95% (HPLC)
• biological source: Uncaria rhynchophylla
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: N21[C@H]([C@@]3(CC2)c4c(cccc4)NC3=O)C[C@@H]([C@H](C1)CC)\C(=C/OC)\C(=O)OC
• InChI: 1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1
• InChI key: DAXYUDFNWXHGBE-KAXDATADSA-N

Opis

Biochem/physiol Actions

Rhynchophylline is a spirocyclic alkaloid isolated from Uncaria species that exibits numerous pharmacological activities including hypotensive, neuroprotective, anticonvulsive, antiepileptic, antiarrhythmic, anticoagulant, antispasmodic, and sedative. Rhynchophylline modulates voltage-gated K+ (Kv) channel slow inactivation in mouse neuroblastoma N2A cells. Also it acts as noncompetitive antagonists of NMDA receptor channels in Xenopus oocytes.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H300
• Ostrzeżenia: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable