SML3905

FerroLOXIN-2

≥98% (HPLC)

• Synonim(y): N-(3-Bromo-4-(trifluoromethyl)benzyl)-1-(3-fluorophenyl)-4-phenyl-1H-imidazol-2-amine trifluoroacetate, N-[[3-Bromo-4-(trifluoromethyl)phenyl]methyl]-1-(3-fluorophenyl)-4-phenyl-1H-imidazol-2-amine trifluoroacetate
• Wzór empiryczny (zapis Hilla): C₂₃H₁₆BrF₄N₃ ·CF₃CO₂H
• Numer CAS: 2773428-35-4
• Masa cząsteczkowa: 604.31
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Opis

Biochem/physiol Actions

15LOX/PEBP1 catalytic complex inhibitor that prevents cell death by ferroptosis, but not necroptosis, pyroptosis, or apoptosis.

FerroLOXIN-2 is a ferroptosis inhibitor that selectively targets the 15LOX/PEBP1 catalytic complex without affecting the biosynthesis of pro-/anti-inflammatory lipid mediators. FerroLOXIN-2 prevents 0.5 μM GPX4 inhibitor RSL3-induced ferroptosis in HBE cell cultures (IC50 = 97 nM post 20h RSL3 treatment) and rescues mice from total body irradiation (TBI)-induced death in vivo (Cpd administered via 25 mg/kg ip. 20h post 9.25Gy irradiation; survival on day 30 = 80% vs. 0% on day 19 of untreated control). FerroLOXIN-2 does not exert its efficacy via radical scavenging or iron-chelating activity, nor does it prevent cell death by necroptosis, pyroptosis, or apoptosis.

Disclaimer

Hygroscopic

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable