SML3968

NSI-189

≥98% (HPLC)

• Synonim(y): (4-Benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone, NSI 189, [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone
• Wzór empiryczny (zapis Hilla): C₂₂H₃₀N₄O
• Numer CAS: 1270138-40-3
• Masa cząsteczkowa: 366.50
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD26959792
• Form: powder
• Assay: ≥98% (HPLC)
• Solubility: DMSO: 2 mg/mL, clear
• Color: white to beige

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: N2(CCN(CC2)C(=O)c3c(nccc3)NCCC(C)C)Cc1ccccc1
• InChI: 1S/C22H30N4O/c1-18(2)10-12-24-21-20(9-6-11-23-21)22(27)26-15-13-25(14-16-26)17-19-7-4-3-5-8-19/h3-9,11,18H,10,12-17H2,1-2H3,(H,23,24)
• InChI key: DYTOQURYRYYNOR-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Orally available neurogenic drug that ameliorates impaired memory function in Zucker diabetic fatty rats; exhibits long-acting antidepressant, procognitive, synaptoplastic, and neurotrophic activities.


NSI-189 is an orally available neurogenic drug with pleiotropic properties that ameliorates impaired memory function and plasticity in Zucker diabetic fatty rat model of type 2 diabetes through enhanced expression of mitochondrial complexes I, III, IV, and V. NSI-189 exhibits long-acting antidepressant, procognitive, synaptoplastic, and neurotrophic activities in patients with major depressive disorder.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable