SML4157

FINO2 10% solution in DMSO

≥98% (HPLC), solution

• Synonim(y): rel-(5α,8α)-8-(1,1-Dimethylethyl)-3-methyl-1,2-dioxaspiro[4.5]decane-3-ethanol
• Wzór empiryczny (zapis Hilla): C₁₅H₂₈O₃
• Masa cząsteczkowa: 256.38
• MDL number: MFCD34790783
• UNSPSC Code: 12352203
• Assay: ≥98% (HPLC)
• Form: solution

Właściwości

• assay: ≥98% (HPLC)
• form: solution
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Opis

Application

FINO2 is used as aresearch tool to study pathways of ferroptosis and to probe explore how thesepathways relate to diseases including Alzheimer’s, Parkinson’s andcardiovascular diseases.

Biochem/physiol Actions

FINO2 is a novel inducer of ferroptosis. It acts in a different manner than class 1 inducers, which deplete glutathione by inhibiting cystine import via system xc−, or class 2 inihbitors, which covalently inhibit glutathione peroxidase 4 (GPX4). FINO2 has a two-fold mechanism of action. It indirectly inhibits the enzymatic of glutathione peroxidase 4 (GPX4) and directly oxidizes iron, leading to widespread lipid peroxidation and eventual cell death. FINO2 was found to be more potent in cancer cells than in nonmalignant cells of the same type.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H242
• Ostrzeżenia: P210 - P234 - P235 - P280 - P370 + P378 - P410
• Hazard Classifications: Org. Perox. C
• Klasa składowania: 5.2 - Organic peroxides and self-reacting hazardous materials
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable