SML4239

Phenoxodiol

≥98% (HPLC), powder, tNOX (ENOX2) inhibitor

• Synonim(y): 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol; 3-(4-Hydroxyphenyl)-2H-benzopyran-7-ol, Haginin E, Idronoxil, Dehydroequol, NV 06
• Wzór empiryczny (zapis Hilla): C₁₅H₁₂O₃
• Numer CAS: 81267-65-4
• Masa cząsteczkowa: 240.25
• MDL number: MFCD06636630
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to pink
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Opis

Application

Phenoxodiol may be used to study immunomodulatory effects on human peripheral blood mononuclear cells in in vitro and in vivo assays.

Biochem/physiol Actions

Phenoxodiol, an isoflavene, is a broad-spectrum anti-tumor agent that causes apoptosis via both intrinsic and extrinsic pathways. It is a pan-cancer drug that targets plasma membrane electron transport (PMET). It also acts as a potent sensitizer of most standard chemotoxic agents. Phenoxodiol inhibits tumor-specific NADH oxidase tNOX (ENOX2) and DNA topoisomerase II. It blocks phosphorylation and activation of several different pro-survival signaling proteins including sphingosine kinase and Akt. It is also known to inhibit tyrosine kinases and X-linked inhibitor of apoptosis.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07,GHS09
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302,H400
• Ostrzeżenia: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): No data available
• Temperatura zapłonu (°C): No data available