SML4305

Ceftiofur sodium salt

≥98% (HPLC), powder, antibiotic

• Synonim(y): (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt, Sodium (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((furan-2-carbonyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, Ceftiofur sodium, U 64279E
• Wzór empiryczny (zapis Hilla): C₁₉H₁₆N₅NaO₇S₃
• Numer CAS: 104010-37-9
• Masa cząsteczkowa: 545.54
• MDL number: MFCD01766184
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C

Opis

General description

Ceftiofur sodium salt, a third-generation β-lactam antibiotic, exhibits broad-spectrum bactericidal activity against many veterinary pathogens.

potent, broad-spectrum β-lactam bactericidally inhibits bacterial cell wall synthesis via PBP binding, its active metabolite boosting veterinary efficacy and ensuring safety.

Ceftiofur sodium salt a third-generation β-lactam antibiotic, exhibits broad-spectrum bactericidal activity against many veterinary pathogens. Its core mechanism disrupts bacterial cell wall synthesis by irreversibly inactivating penicillin-binding proteins (PBPs) on the inner bacterial membrane, causing cell lysis. It shows potent activity with low MIC values against key pathogens like Pasteurella multocida (MIC90 ≤ 0.03 µg/ml) and Actinobacillus pleuropneumoniae (MIC90 ≤ 0.125 µg/ml). Parenterally administered due to poor oral absorption, ceftiofur rapidly metabolizes in vivo to desfuroylceftiofur (DFC), an equally active metabolite enhancing its efficacy. With a good therapeutic safety profile, ceftiofur is a significant veterinary antimicrobial for susceptible infections.

Application

Ceftiofur sodium salt may be used in the assessment of biodegradation mechanisms of ceftiofur sodium by Escherichia sp. CS-1.

Biochem/physiol Actions

Ceftiofur sodium salt disrupts bacterial cell wall synthesis by irreversibly inactivating penicillin-binding proteins (PBPs) on the inner bacterial membrane, causing cell lysis. It shows potent activity with low MIC values against key pathogens like Pasteurella multocida (MIC90 ≤ 0.03 µg/ml) and Actinobacillus pleuropneumoniae (MIC90 ≤ 0.125 µg/ml). Parenterally administered due to poor oral absorption, ceftiofur rapidly metabolizes in vivo to desfuroylceftiofur (DFC), an equally active metabolite enhancing its efficacy. With a good therapeutic safety profile, ceftiofur is a significant veterinary antimicrobial for susceptible infections.

Disclaimer

Hygroscopic Store with desiccant

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H317,H334
• Ostrzeżenia: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable