SML4330

MN714

≥98% (HPLC)

• Synonim(y): (S)-4-(3-((3-(2-Chloroacetamido)benzyl)amino)-2-(2-(4-fluorophenyl)acetamido)-3-oxopropyl)phenyl dipivaloyloxymethyl phosphate, MN 714, MN-714
• Wzór empiryczny (zapis Hilla): C₃₈H₄₆ClFN₃O₁₁P
• Masa cząsteczkowa: 806.21
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Opis

Biochem/physiol Actions

MN714 is a cell-permeable pivaloyloxymethyl (POM) ester precursor of MN551, an E3 ligase suppressor of cytokine signaling 2 (SOCS2) inhibitor. Upon entering cells, MN714 is hydrolyzed by cellular esterases to MN551 that covalently modifies SOCS2 SH2 domain EF loop Cys111. MN551 also effectively modifies SH2 containing protein (CISH) (Cys114), but not SOCS4 (Cys350) or SOCS6 (no EF loop Cys). MN714 treatment of K562 cells (10 µM for 6h) prior to lysate preparation compeletly abrogates endogenous SOCS2 binding of immobilized GHR pY595 substrate peptide.

Disclaimer

Hygroscopic, Store with desiccant

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable