SML4350

UAMC-4821

≥98% (HPLC)

• Synonim(y): UAMC-4821 Ferroptosis inhibitor, UAMC4821, UAMC 4821
• Wzór empiryczny (zapis Hilla): C₁₅H₁₉N₃O
• Numer CAS: 3094522-02-5
• Masa cząsteczkowa: 257.33
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Opis

Biochem/physiol Actions

UAMC-4821, a lipophilic radical-trapping antioxidant (RTA) and potent, orally bioavailable ferroptosis inhibitor, is designed to surpass the limitations of ferrostatin-1 and UAMC-3203. Demonstrating high potency (IC50 = 5.20 nM in HT-1080 cells, with FENIX assay confirming RTA activity), UAMC 4821 exhibits excellent oral bioavailability (63% in mice), low clearance, and high brain concentrations (123 ng/g after 24h, IV 10 mg/kg in mice), indicating superior ADME properties and blood-brain barrier penetration over earlier ferrostatins. Functionally, UAMC4821 directly neutralizes lipid peroxyl radicals within phospholipid bilayers, preventing membrane damage and ferroptotic death, thereby enhancing its attractiveness for CNS-targeted explorations.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302,H317
• Ostrzeżenia: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1B
• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable