SML4427

ERK-MYD88 PPI inhibitor EI-52

≥98% (HPLC)

• Synonim(y): 2-[4-(Dimethyl-amino)phenyl]-N-(6-methoxy-3-pyridinyl)-1H-benzimidazole-6-carboxamide hydrate, EI-52
• Wzór empiryczny (zapis Hilla): C₂₂H₂₁N₅O₂ · xH₂O
• Masa cząsteczkowa: 387.43 (anhydrous basis)
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: gray to very dark black-purple
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Opis

Biochem/physiol Actions

EI-52, a benzimidazole, is a potent and selective inhibitor of ERK-MYD88 interaction (IC50 = 3.1μM). EI-52 binds to the ERK D-recruitment site (DRS) without influence on ERK (ERK1 and ERK2) kinase activity and potently disrupts ERK-MYD88 interaction leading to immunogenic apoptosis specific to cancer cells. ERK-MYD88 PPI inhibitor EI-52 exhibits antitumor activity in mice models and in patient-derived tumor organoids. EI-52 induces an anti-tumor T cell response in mice in vivo.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302,H317
• Ostrzeżenia: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1B
• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable