SML4465

L-Homopropargylglycine hydrochloride

≥98% (HPLC)

• Synonim(y): (2S)-2-Aminohex-5-ynoic acid hydrochloride, HCl, HPG
• Wzór empiryczny (zapis Hilla): C₆H₉NO₂
• Numer CAS: 98891-36-2
• Masa cząsteczkowa: 127.14
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Opis

Biochem/physiol Actions

L-Homopropargylglycine (HPG) is a cell-permeable, non-canonical amino acid and structural analog of L-methionine, possessing a terminal alkyne (–C≡CH) group as a bioorthogonal handle. This structure is recognized by the native, wild-type methionyl-tRNA synthetase (MetRS), which mediates its incorporation into nascent polypeptide chains at methionine positions during ribosomal synthesis. Because MetRS promiscuously charges HPG onto tRNAᴹᵉᵗ in most cell types, this results in broad, non-specific labeling of the translatome. The incorporated alkyne handle serves as a versatile platform for covalent ligation via click chemistry, enabling either fluorescent visualization (FUNCAT) or affinity enrichment (BONCAT) of newly synthesized proteins. While lacking cell-type specificity, HPG provides an accessible and powerful tool for monitoring global proteome dynamics.

Disclaimer

Hygroscopic, Store with desiccant

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H242
• Ostrzeżenia: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Klasa składowania: 5.2 - Organic peroxides and self-reacting hazardous materials
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable