SML4480

Gambogenic acid

≥98% (HPLC)

• Synonim(y): (-)-Gambogenic acid, (2Z)-4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-2-butenoic acid
• Wzór empiryczny (zapis Hilla): C₃₈H₄₆O₈
• Numer CAS: 173932-75-7
• Masa cząsteczkowa: 630.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Opis

Biochem/physiol Actions

Gambogenic acid (GNA) is a promising antitumor agent targeting EZH2 and modulating signaling pathways to inhibit proliferation, metastasis, enhance chemosensitivity, and overcome drug resistance. Acting in a time- and dose-dependent manner, GNA targets cancer hallmarks with broad activity by directly and covalently binding EZH2 (Cys668), disrupting PRC2, activating RIP1/p53/SLC7A11/GPX4, activating GSK3β while inhibiting Akt/mTOR, inducing ferroptosis, and downregulating metastasis proteins. These actions, mediated through pathways like Akt/mTOR, ROS/JNK, and NF-ĸB, result in tumor cell death and proliferation reduction, with GNA showing advantages over gambogic acid in antitumor effect and toxicity. In vitro and in vivo studies confirm GNA′s efficacy, but consideration should be given to potential drug-drug interactions due to GNA′s increase of liver CYP enzyme activity.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable