T182

Tyrphostin A9

solid

• Synonim(y): Malonoben, [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile
• Wzór empiryczny (zapis Hilla): C₁₈H₂₂N₂O
• Numer CAS: 10537-47-0
• Masa cząsteczkowa: 282.38
• NACRES: NA.77
• PubChem Substance ID: 24278069
• UNSPSC Code: 51111800
• MDL number: MFCD00209853
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: yellow
• mp: 139-140 °C
• solubility: ethanol: 20 mg/mL, DMSO: <25 mg/mL, H₂O: insoluble
• SMILES string: CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C
• InChI: 1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3
• InChI key: MZOPWQKISXCCTP-UHFFFAOYSA-N
• Gene Information: human ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159) ; mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779) ;

Opis

Application

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

Biochem/physiol Actions

Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301 + H311
• Ostrzeżenia: P280 - P301 + P310 + P330 - P302 + P352 + P312
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges